Neuroinflammation and Neurodegeneration Mechanisms

Association of microglia loss with hippocampal network impairments as a turning point in the amyloid pathology progression.

The paper investigates how microglia loss in the hippocampus contributes to early amyloid pathology progression by disrupting neural oscillations and synaptic function in a mouse model.

Type I interferon responsive microglia shape cortical development and behavior

This study identifies a Type I interferon-responsive microglial subset that engulfs neurons during brain development and shows its role in shaping cortical structure and behavior.

Chronic IL-6 overproduction induces a tolerogenic response in aged mice after peripheral nerve injury

This study shows chronic IL-6 overproduction in aged mice primes microglia but does not worsen outcomes after facial nerve injury, suggesting a tolerogenic effect.

A Trisomy 21-linked Hematopoietic Gene Variant in Microglia Confers Resilience in Human iPSC Models of Alzheimers Disease

This paper introduces a trisomy 21-linked CSF2RB mutation in microglia that reduces neuroinflammation and enhances phagocytic functions, offering potential for AD therapy.

Deletion of the microglial transmembrane immune signaling adaptor TYROBP ameliorates Huntington's disease mouse phenotype

This study shows that deleting TYROBP in HD mice reduces microglial activation and improves motor deficits without correcting neuronal gene expression.

Brain-Penetrant NF-κB and NLRP3 Targeting Nanoligomers are Therapeutic in Amyotrophic Lateral Sclerosis (ALS) and Alzheimers Disease (AD) Human Organoid and Mouse Models

This paper demonstrates that NI112, a brain-penetrant Nanoligomer targeting NF-κB and NLRP3, improves functional outcomes and reduces neuroinflammation in ALS and AD human organoid and mouse models.

Reactive microglia fail to respond to environmental damage signals in a viral-induced mouse model of temporal lobe epilepsy

The paper investigates microglial response to damage signals in a viral-induced mouse model of temporal lobe epilepsy, finding reduced P2ry12 expression and increased TNF-a during seizures and infection.

Long-access heroin self-administration induces region specific reduction of grey matter volume and microglia reactivity in the rat.

This study shows that long-access heroin self-administration in rats reduces grey matter volume in specific brain regions and alters microglia morphology, suggesting a link between neuroinflammation and structural brain changes.

TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease models

This study shows that TREM1 deficiency prevents age-related myeloid metabolic changes and cognitive decline in Alzheimer's disease models.

Secondary microglia formation center in the human fetal brain

The paper identifies a proliferative microglia aggregate in human fetal brain development that may serve as a secondary microglial formation center.

NF-kB/NLRP3 Translational Inhibition by Nanoligomer Therapy Mitigates Ethanol and Advanced Age-Related Neuroinflammation

This study shows that binge ethanol increases NLRP3+ microglia in aged mice, and that Nanoligomer therapy reduces ethanol-induced neuroinflammation and tau hyperphosphorylation.

S100A8-enriched microglia populate the brain of tau-seeded and accelerated aging mice

The paper identifies S100A8-enriched microglia in tauopathy and accelerated aging mouse models, showing their presence in human AD and tauopathy biopsies.

Pathologic α-Synuclein-NOD2 Interaction and RIPK2 Activation Drives Microglia-Induced Neuroinflammation in Parkinson's Disease

This paper identifies NOD2/RIPK2 signaling as a key driver of neuroinflammation in Parkinson's disease, showing that pathological α-synuclein activates this pathway in microglia, leading to neurodegeneration and that targeting NOD2 or RIPK2 protects dopamine neurons.

Anti-apoptotic and anti-inflammatory properties of grapefruit IntegroPectin on human microglial HMC3 cell line

This study shows grapefruit IntegroPectin reduces apoptosis and inflammation in microglial cells under oxidative stress by modulating PI3K pathways.

Selective deletion of interleukin-1 alpha in microglia does not modify acute outcome but regulates neurorepair processes after experimental ischemic stroke.

This study investigates the role of microglial-derived IL-1 in experimental ischemic stroke, finding it does not affect acute damage but influences neurorepair and functional recovery.

Transient Impairment in Microglial Function Causes Sex-Specific Deficits in Synaptic and Hippocampal Function in Mice Exposed to Early Adversity

This study shows that early adversity impairs microglial function in male mice, causing synaptic and behavioral deficits, while females show resilience through astrocytic compensation.

Microglia/macrophage-specific deletion of TLR-4 protects against neural effects of diet-induced obesity

This study shows that deleting TLR4 in microglia/macrophages reduces neuroinflammation and cognitive impairments in diet-induced obesity, with sex-specific effects.

Amelioration of signalling deficits underlying metabolic shortfall in TREM2R47H human iPSC-derived microglia

This study investigates how metabolite supplementation affects metabolic and functional deficits in TREM2-mutant human iPSC-derived microglia, identifying distinct effects of citrate and succinate on mitochondrial function and phagocytosis.

BRI2-mediated regulation of TREM2 processing in microglia and its potential implications for Alzheimer's disease and related dementias

The paper shows BRI2 regulates TREM2 processing in microglia, affecting Alzheimer's disease risk, and suggests BRI2 as a therapeutic target.

Impaired 26S proteasome causes learning and memory deficiency and induces neuroinflammation mediated by NF-κB in mice

A pharmacological toolkit for human microglia identifies Topoisomerase I inhibitors as immunomodulators for Alzheimer's disease

The paper identifies Topoisomerase I inhibitors as immunomodulators for Alzheimer's disease by characterizing their effects on human microglial subtypes in vitro and in a zebrafish model.

An axon - T cell feedback loop enhances inflammation and axon degeneration

The paper shows that a feedback loop between axons and T cells exacerbates inflammation and axon degeneration in mouse skin.

Radiotherapy induces persistent innate immune reprogramming of microglia into a primed state

This study shows that radiotherapy primes microglia in rats to have a heightened immune response to future inflammation, and this effect is observed in human brain tissue.

SRF-deficient astrocytes provide neuroprotection in mouse models of excitotoxicity and neurodegeneration

This study shows that deleting SRF in astrocytes creates neuroprotective astrocytes that reduce neuronal damage in mouse models of excitotoxicity and neurodegenerative diseases.

Transcriptional characterization of iPSC-derived microglia as a model for therapeutic development in neurodegeneration

This study assesses iPSC-derived microglia-like cells using bulk and single-cell RNA sequencing, showing they resemble primary human microglia in gene expression and respond to LXR agonists.

Exploring social modulation: Microglia as a key mediator of individual immune response, plasticity and pathology in App-NL-G-F mouse model of Alzheimer's disease

This study investigates how social environment affects Alzheimer's disease progression in App-NL-G-F mice, showing social deficits precede pathology and linking microglia activation to neuroinflammation and neurogenesis.

ER and SOCE Ca2+ signals are not required for directed cell migration in human microglia

This study shows that ER and SOCE Ca2+ signals are not required for directed migration of human microglia in response to purinergic stimuli, suggesting a Ca2+-independent mechanism involving cyclic AMP.

Changes in microglia chromatin accessibility in aged female mice.

This study identifies age-related changes in chromatin accessibility in female microglia, showing more gains than losses in accessibility, enriched in immune-related genes and intergenic regions.

CXCR3-expressing myeloid cells recruited to the hypothalamus protect against diet-induced body mass gain and metabolic dysfunction

This study identifies transcriptional differences between resident and recruited hypothalamic microglia in diet-induced obesity, showing that CXCR3-expressing recruited cells protect against metabolic dysfunction.

DUALISTIC SAHA DOSE-DEPENDENT EFFECTS ON GLIAL-INFLAMMATORY RESPONSE

This study examines how different doses of HDAC inhibitors TSA and SAHA affect glial inflammatory responses to LPS, showing dose-dependent pro- and anti-inflammatory effects.